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Author Zhang, Rui ♦ Zhang, Xulun ♦ Bian, Feng ♦ Pu, Xin an ♦ Schilling, Karl ♦ Oberdick, John
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2008
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Transgenic mouse ♦ Cerebellum ♦ Dendritic targeting ♦ GoLoco ♦ P/Q-type Ca$^{2+}$ channel ♦ In situ hybridization ♦ Neurology ♦ Neurobiology ♦ Neurosciences
Abstract Pcp2(L7) is a Purkinje cell-specific GoLoco domain protein that modulates activation of Gαi/o proteins by G protein-coupled receptors. A likely downstream effector of this pathway is the P-type Ca$^{2+}$ channel, and thereby, the intrinsic electrophysiology of Purkinje cells could be modulated by Pcp2(L7). It has long been known that the Pcp2(L7) mRNA is abundantly localized in dendrites, suggesting the possibility of distal synthesis and local changes in levels of the protein. As a first step to uncover the trafficking and translational mechanisms for this mRNA, we have begun identifying the cis-acting sequences important for its localization in dendrites. Using expression of modified transgenes in vivo, we show that the 3′UTR, only 65 bases long, is necessary in this process.
ISSN 14734222
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2008-09-04
Publisher Place New York
e-ISSN 14734230
Journal The Cerebellum
Volume Number 7
Issue Number 3
Page Count 12
Starting Page 482
Ending Page 493


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Source: SpringerLink