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Author Carbone, Kathryn M. ♦ Pletnikov, Mikhail V. ♦ Rubin, Steven A. ♦ Moran, Timothy H.
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2003
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Borna ♦ cerebellum ♦ developmental disorders ♦ animal models ♦ Neurosciences ♦ Neurobiology ♦ Neurology
Abstract Cerebellar pathology has been associated with a number of developmental behavioral disorders, including autism spectrum disorders. Despite the fact that perinatal virus infections have been implicated in neurodevelopmental damage, few animal models have been developed to study the pathogenesis involved. One of the most interesting in vivo models of virus-induced cerebellar damage is the neonatal Borna disease virus (BDV) infection of the rat brain. The present review describes molecular, cellular, neuroanatomical, neurochemical and behavioral features of the BDV model and also provides a basis for a new understanding of the pathogenic mechanisms of cerebellar malformation and associated behavioral deficits.
ISSN 14734222
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2003-01-01
Publisher Place New York
e-ISSN 14734230
Journal The Cerebellum
Volume Number 2
Issue Number 1
Page Count 9
Starting Page 62
Ending Page 70

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Source: SpringerLink