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Author Oostland, Marlies ♦ Buijink, M. Renate ♦ Teunisse, Guus M. ♦ Oerthel, Lars ♦ Smidt, Marten P. ♦ Hooft, Johannes A.
Source SpringerLink
Content type Text
Publisher Springer US
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Serotonin receptors ♦ Cerebellum ♦ Synaptic plasticity ♦ Neurosciences ♦ Neurology ♦ Neurobiology
Abstract Serotonin plays an important role of controlling the physiology of the cerebellum. However, serotonin receptor expression has not been fully studied in the developing cerebellum. We have recently shown that cerebellar granule cells transiently express 5-HT$_{3}$ receptors. In the present study, we investigate expression of 5-HT$_{1}$ and 5-HT$_{2}$ receptors in the mouse cerebellum both during postnatal development and in juvenile mice. Here, we show for the first time that 5-HT$_{1A}$ and 5-HT$_{2A}$ receptors are present on cerebellar granule cells with a distinct temporal expression pattern: 5-HT$_{1A}$ receptors are expressed only during the first 2 weeks, while 5-HT$_{2A}$ receptor expression persists until at least 8 weeks after birth. Because of its prolonged expression pattern, we investigated the electrophysiological properties of the 5-HT$_{2A}$ receptor. 5-HT$_{2A}$ receptors expressed by cerebellar granule cells promote stability by reducing variability of the synaptic response, and they modulate the paired-pulse ratio of the parallel fibre–Purkinje cell synapse. Furthermore, pharmacological block of 5-HT$_{2A}$ receptors enhances short-term synaptic plasticity at the parallel fibre–Purkinje cell synapse. We thus show a novel role for serotonin in controlling function of the cerebellum via 5-HT$_{2A}$ receptors expressed by cerebellar granule cells.
ISSN 14734222
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-05-01
Publisher Place Boston
e-ISSN 14734230
Journal The Cerebellum
Volume Number 13
Issue Number 4
Page Count 10
Starting Page 491
Ending Page 500


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Source: SpringerLink