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Author El Meskini, Rajaâ ♦ Boudouresque, Françoise ♦ Ouafik, L’Houcine
Source Paperity
Content type Text
Publisher Oxford University Press
File Format PDF ♦ HTM / HTML
Copyright Year ©1997
Abstract Peptidylglycine α-amidating monooxygenase (PAM; EC is a bifunctional protein containing two enzymes that act sequentially to catalyze the conversion of glycine-extended peptides into COOH-terminal amidated peptides. We have previously shown that PAM messenger RNA (mRNA) levels in the anterior pituitary of intact cycling adult female rats showed changes inversely related to the physiological variations of plasma estrogen levels during the estrous cycle. Chronic treatment of ovariectomized (OVX) rats with 17β-estradiol was accompanied by a 4.5 ± 0.5-fold decrease in total PAM mRNA and a 2-fold decrease in PAM activity in the anterior pituitary gland.
Learning Resource Type Article
Publisher Date 1997-12-01
Journal Endocrinology
Volume Number 138
Issue Number 12