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Author Sevostyanova, V. V. ♦ Khodyrevskaya, Y. I. ♦ Glushkova, T. V. ♦ Antonova, L. V. ♦ Kudryavtseva, Y. A. ♦ Barbarash, O. L. ♦ Barbarash, L. S.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ANIMAL TISSUES ♦ CARDIOVASCULAR SYSTEM ♦ COMPARATIVE EVALUATIONS ♦ ENZYMES ♦ GRAFTS ♦ GROWTH FACTORS ♦ LACTONES ♦ MECHANICAL PROPERTIES ♦ POROUS MATERIALS ♦ SCANNING ELECTRON MICROSCOPY ♦ SURGERY
Abstract The development of tissue-engineered small-diameter vascular grafts is an urgent issue in cardiovascular surgery. In this study, we assessed how the incorporation of the vascular endothelial growth factor (VEGF) affects morphological and mechanical properties of polycaprolactone (PCL) vascular grafts along with its release kinetics. Vascular grafts were prepared using two-phase electrospinning. In pursuing our aims, we performed scanning electron microscopy, mechanical testing, and enzyme-linked immunosorbent assay. Our results demonstrated the preservation of a highly porous structure and improvement of PCL/VEGF scaffold mechanical properties as compared to PCL grafts. A prolonged VEGF release testifies the use of this construct as a scaffold for tissue-engineered vascular grafts.
ISSN 0094243X
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-10-27
Publisher Place United States
Volume Number 1683
Issue Number 1


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