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Author Goldstein, D. S. ♦ Chang, P. C. ♦ Smith, C. B. ♦ Herscovitch, P. ♦ Austin, S. M. ♦ Eisenhofer, G. ♦ Kopin, I. J.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ RADIOLOGY AND NUCLEAR MEDICINE ♦ AUTONOMIC NERVOUS SYSTEM ♦ DYNAMIC FUNCTION STUDIES ♦ ORGANS ♦ RADIATION DOSES ♦ RADIOPHARMACEUTICALS ♦ TISSUE DISTRIBUTION ♦ DOGS ♦ DOPAMINE ♦ FLUORINE 18 ♦ METABOLISM ♦ POSITRON COMPUTED TOMOGRAPHY ♦ RADIONUCLIDE KINETICS ♦ RATS ♦ AMINES ♦ ANIMALS ♦ AROMATICS ♦ AUTONOMIC NERVOUS SYSTEM AGENTS ♦ BETA DECAY RADIOISOTOPES ♦ BETA-PLUS DECAY RADIOISOTOPES ♦ BODY ♦ CARDIOTONICS ♦ CARDIOVASCULAR AGENTS ♦ COMPUTERIZED TOMOGRAPHY ♦ DIAGNOSTIC TECHNIQUES ♦ DISTRIBUTION ♦ DOSES ♦ DRUGS ♦ EMISSION COMPUTED TOMOGRAPHY ♦ FLUORINE ISOTOPES ♦ HOURS LIVING RADIOISOTOPES ♦ HYDROXY COMPOUNDS ♦ ISOMERIC TRANSITION ISOTOPES ♦ ISOTOPES ♦ LABELLED COMPOUNDS ♦ LIGHT NUCLEI ♦ MAMMALS ♦ NERVOUS SYSTEM ♦ NEUROREGULATORS ♦ NUCLEI ♦ ODD-ODD NUCLEI ♦ ORGANIC COMPOUNDS ♦ PHENOLS ♦ POLYPHENOLS ♦ RADIOISOTOPES ♦ RODENTS ♦ SYMPATHOMIMETICS ♦ TOMOGRAPHY ♦ VERTEBRATES ♦ Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells ♦ Medicine- Unsealed Radionuclides in Diagnostics
Abstract Positron emission tomographic (PET) scanning after systemic i.v. injection of fluorine-18-6-fluorodopamine (({sup 18}F)-6F-DA) is a method for visualizing and measuring regional sympathetic nervous system innervation and function. Based on results of preclinical studies of rats and dogs and on previous literature about the fate of injected tracer-labeled catecholamines, dosimetric estimates for clinical studies are presented here. After injection of 1 mCi of ({sup 18}F)-F-DA, the radiation dose would be highest to the wall of the urinary bladder (1.40 rem/mCi), due to accumulation of radioactive metabolites of ({sup 18}F)-F-DA in urine. Radioactivity also would accumulate in bile. Organs receiving the next highest dose would be the kidneys (0.9 rem/mCi) and small intestine (0.2 rem/mCi). The parenchymal radiation dose would be lowest in the brain, since there is an effective blood-brain barrier for circulating catecholamines. Radiation doses to all organs after administration of 1 mCi of ({sup 18}F)-F-DA to humans would be less than 3 rem and, therefore, within current FDA guidelines.
ISSN 01615505
Educational Use Research
Learning Resource Type Article
Publisher Date 1991-01-01
Publisher Place United States
Journal Journal of Nuclear Medicine
Volume Number 32
Issue Number 1