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Author Ohta, N. ♦ Saito, H. ♦ Kaneko, T. ♦ Yoshida, M. ♦ Takahashi, T. ♦ Saito, T. ♦ Nakahara, K. ♦ Hiroi, M.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Springer
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Gynecology, obstetrics, pediatrics & geriatrics ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Urogenital System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Polycyclic Compounds ♦ Hormones, Hormone Substitutes, and Hormone Antagonists ♦ Carbohydrates ♦ Chemicals and Drugs ♦ Therapeutics ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Chemical Phenomena ♦ Reproductive and Urinary Physiological Phenomena ♦ Biological Sciences
Subject Keyword Discipline Reproductive Medicine ♦ Discipline Genectics ♦ Antigens, Cd44 ♦ Physiology ♦ Fertilization In Vitro ♦ Follicular Fluid ♦ Immunology ♦ Analysis ♦ Chorionic Gonadotropin ♦ Estradiol ♦ Female ♦ Chemistry ♦ Humans ♦ Male ♦ Ovarian Follicle ♦ Predictive Value Of Tests ♦ Pregnancy ♦ Solubility ♦ Statistics, Nonparametric ♦ Testosterone ♦ Journal Article
Abstract PURPOSE: In the present study, we investigated the existence of soluble CD44 (sCD44) in human follicular fluid, the relationship between the concentration of sCD44 and that of other hormonal parameters, and the prognostic value of sCD44 in follicular fluid in in vitro fertilization (IVF) programs. METHODS: A total of 63 follicular fluid specimens from patients (n = 30) participating in our IVF programs was analyzed by RIA and enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean concentration (+/- SE) of sCD44 in follicular fluid was 265.4 +/- 7.8 ng/ml. The variation of the follicular fluid concentration of sCD44 was strictly associated with that of human chorionic gonadotropin (hCG) (r = 0.572, P < 0.0001). The mean concentration of sCD44 in follicular fluid was significantly higher in follicles containing subsequently unfertilized oocytes than that in those containing oocytes that had undergone fertilization (P = 0.0428). In the analysis of each follicle that contained an oocyte subsequently fertilized, the mean concentration of sCD44 was significantly higher in follicular fluid with the subsequently good-quality embryos than in that with the subsequently poor-quality embryos (P < 0.05). CONCLUSIONS: These results indicated that the concentration of sCD44 in follicular fluid reflects the development of embryos derived from the same follicle, so the sCD44 in human follicular fluid may be useful in the assessment of the prognostic value of IVF programs.
Description Country affiliation: Japan
Author Affiliation: Ohta N ( Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata City 990-9585, Japan. nohta@omn.ne.jp)
ISSN 10580468
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2001-01-01
Publisher Place Netherlands
e-ISSN 15737330
Journal Journal of Assisted Reproduction and Genetics
Volume Number 18
Issue Number 1


Source: WHO-Global Index Medicus