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Author Detti, Laura ♦ Jeffries-Boyd, Heather E. ♦ Williams, Lucy J. ♦ Diamond, Michael P. ♦ Uhlmann, Rebecca A.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Springer
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Diseases ♦ Gynecology, obstetrics, pediatrics & geriatrics ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Neoplasms ♦ Female Urogenital Diseases and Pregnancy Complications ♦ Nutritional and Metabolic Diseases ♦ Diseases ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Persons ♦ Persons
Subject Keyword Discipline Reproductive Medicine ♦ Discipline Genectics ♦ Metabolic Diseases ♦ Metabolism ♦ Polycystic Ovary Syndrome ♦ Adult ♦ Biological Markers ♦ Cross-sectional Studies ♦ Female ♦ Glucose Intolerance ♦ Complications ♦ Humans ♦ Infertility, Female ♦ Logistic Models ♦ Roc Curve ♦ Risk Factors ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract PURPOSE: We sought to evaluate the relationship between the polycystic ovary syndrome (PCOS)-defining characteristics and the risk of developing metabolic complications in women presenting with complaints of infertility and/or menstrual irregularities and subsequently diagnosed with PCOS. METHODS: This was a cross-sectional study. Women presenting with complaints of infertility and/or irregular menses and diagnosed with PCOS by the Rotterdam criteria, underwent endocrine, metabolic, and ultrasound assessment in the early follicular phase. Reproductive and metabolic parameters were included in regression analysis models with the PCOS-defining characteristics; ROC curves were calculated for the significant predictors. RESULTS: Three hundred and seventy-four women with PCOS were included in our study. Oligo-anovulation, menstrual irregularities, and hirsutism were not predictive of any of the variables. Ovarian volume, follicle count, and biochemical hyperandrogenism were predictors for hormonal, metabolic, and endometrial complications. The relationships were independent of age and body mass index. ROC curves identified lower cut-off values of the PCOS-defining characteristics to predict patients' risks of hyperinsulinemia, dyslipidemia, and glucose intolerance. CONCLUSIONS: Adverse metabolic effects of PCOS are already present in women at the time they present complaining of infertility and/or irregular menses. Hyperandrogenism and ultrasound can assist in predicting the patients' concomitant metabolic abnormalities and can aid physicians in tailoring counseling for effective preventive strategies.
Description Country affiliation: United States
Author Affiliation: Detti L ( Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee Health Science Center, Rout Center, 853 Jefferson Ave, Rm E102, Memphis, TN, 38163, USA. ldetti@uthsc.edu.); Jeffries-Boyd HE ( Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee Health Science Center, Rout Center, 853 Jefferson Ave, Rm E102, Memphis, TN, 38163, USA.); Williams LJ ( Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee Health Science Center, Rout Center, 853 Jefferson Ave, Rm E102, Memphis, TN, 38163, USA.); Diamond MP ( Department of Obstetrics and Gynecology, Georgia Regents University, Augusta, GA, USA.); Uhlmann RA ( Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee Health Science Center, Rout Center, 853 Jefferson Ave, Rm E102, Memphis, TN, 38163, USA.)
ISSN 10580468
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-12-01
Publisher Place Netherlands
e-ISSN 15737330
Journal Journal of Assisted Reproduction and Genetics
Volume Number 32
Issue Number 12


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Source: WHO-Global Index Medicus