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Author Hafeez, Shaista ♦ McDonald, Fiona ♦ Lalondrelle, Susan ♦ McNair, Helen ♦ Warren-Oseni, Karole ♦ Jones, Kelly ♦ Harris, Victoria ♦ Taylor, Helen ♦ Khoo, Vincent ♦ Thomas, Karen ♦ Hansen, Vibeke ♦ Dearnaley, David ♦ Horwich, Alan ♦ Huddart, Robert
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ BLADDER ♦ GY RANGE 10-100 ♦ IMAGES ♦ NEOPLASMS ♦ PATIENTS ♦ RADIATION HAZARDS ♦ RADICALS ♦ RADIOTHERAPY ♦ TOXICITY
Abstract Purpose and Objectives: We report on the clinical outcomes of a phase 2 study assessing image guided hypofractionated weekly radiation therapy in bladder cancer patients unsuitable for radical treatment. Methods and Materials: Fifty-five patients with T2-T4aNx-2M0-1 bladder cancer not suitable for cystectomy or daily radiation therapy treatment were recruited. A “plan of the day” radiation therapy approach was used, treating the whole (empty) bladder to 36 Gy in 6 weekly fractions. Acute toxicity was assessed weekly during radiation therapy, at 6 and 12 weeks using the Common Terminology Criteria for Adverse Events version 3.0. Late toxicity was assessed at 6 months and 12 months using Radiation Therapy Oncology Group grading. Cystoscopy was used to assess local control at 3 months. Cumulative incidence function was used to determine local progression at 1 at 2 years. Death without local progression was treated as a competing risk. Overall survival was estimated using the Kaplan-Meier method. Results: Median age was 86 years (range, 68-97 years). Eighty-seven percent of patients completed their prescribed course of radiation therapy. Genitourinary and gastrointestinal grade 3 acute toxicity was seen in 18% (10/55) and 4% (2/55) of patients, respectively. No grade 4 genitourinary or gastrointestinal toxicity was seen. Grade ≥3 late toxicity (any) at 6 and 12 months was seen in 6.5% (2/31) and 4.3% (1/23) of patients, respectively. Local control after radiation therapy was 92% of assessed patients (60% total population). Cumulative incidence of local progression at 1 year and 2 years for all patients was 7% (95% confidence interval [CI] 2%-17%) and 17% (95% CI 8%-29%), respectively. Overall survival at 1 year was 63% (95% CI 48%-74%). Conclusion: Hypofractionated radiation therapy delivered weekly with a plan of the day approach offers good local control with acceptable toxicity in a patient population not suitable for radical bladder treatment.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-05-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 98
Issue Number 1


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