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Author Voskerician, G. ♦ Chung-Chiun Liu ♦ Anderson, J.M.
Sponsorship IEEE Sensors Council
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2001
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Physics ♦ Electricity & electronics
Subject Keyword In vivo ♦ Biosensors ♦ Sensor phenomena and characterization ♦ Thick film sensors ♦ Monitoring ♦ Electrodes ♦ Scanning electron microscopy ♦ Electrostatic discharge ♦ Testing ♦ Biological materials ♦ electrochemical sensors ♦ Biocompatibility ♦ cyclic voltammetry ♦ diabetes
Abstract This paper assessed the material biocompatibility and investigated the temporal modulation in electrochemical performance of printed thick-film electrochemical sensing devices (ESDs) that can serve as the basis of various enzymatic sensor in detecting an electrochemically potent species. The sensors were placed in phosphate buffered saline (PBS), human serum, or implanted subcutaneously in rats, free or in stainless steel cages. The exudate collection allowed the evaluation of inflammatory cell populations, up to 21 days. The ferrous/ferric redox electrode reactions were used to assess the electrode elements performance for up to 49 days. Following testing, scanning electron microscopy (SEM) evaluated cell surface adhesion, while fibrous capsules were examined by histology. It was determined that the exudates leukocyte concentration due to the presence of sensors was comparable to the empty cage controls. For the length of the study, the sensors functionality appeared not to be influenced by the in vivo environment, when tested ex vivo, without the surrounding fibrous capsule. Surface imaging (SEM) indicated temporal focal dissolution of the Ag/AgCl electrodes with no apparent local toxicity. We concluded that the ESDs were biocompatible and their ex vivo functionality was not lost when maintained in vivo for up to 49 days.
Description Author affiliation :: Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
ISSN 1530437X
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2005-12-01
Publisher Place U.S.A.
Rights Holder Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Volume Number 5
Issue Number 6
Size (in Bytes) 1.82 MB
Page Count 12
Starting Page 1147
Ending Page 1158


Source: IEEE Xplore Digital Library