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Author Parra, Pamela Ochoa ♦ Veloza, Stella
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ BIOMEDICAL RADIOGRAPHY ♦ DETECTION ♦ DOSIMETRY ♦ EMISSION ♦ GALLIUM 68 ♦ HUMAN POPULATIONS ♦ IMPURITIES ♦ NEOPLASMS ♦ POSITRON COMPUTED TOMOGRAPHY ♦ POSITRONS ♦ PROSTATE ♦ RADIOPHARMACEUTICALS ♦ SYNTHESIS ♦ TOXICITY ♦ TRACER TECHNIQUES ♦ UREA
Abstract The radiotracer called {sup 68}Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) is a novel radiophar-maceutical for the detection of prostate cancer lesions by positron emission tomography (PET) imaging. Setting up a cost-effective manual synthesis of this radiotracer and making its clinical translation in Colombia will require two important elements: the evaluation of the procedure to yield a consistent product, meeting standards of radio-chemical purity and low toxicity and then, the evaluation of the radiation dosimetry. In this paper a protocol to extrapolate the biokinetic model made in normal mice to humans by using the computer software for internal dose assessment OLINDA/EXM® is presented as an accurate and standardized method for the calculation of radiation dosimetry estimates.
ISSN 0094243X
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-07-07
Publisher Place United States
Volume Number 1753
Issue Number 1


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