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Author Yuan He ♦ Wen-Chuan Cheng ♦ Yafei Zhao ♦ Lvov, Y. ♦ Long Que
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Technology ♦ Engineering & allied operations ♦ Applied physics
Subject Keyword Drugs ♦ Fluorescence ♦ Optical imaging ♦ Microfluidics ♦ Glass ♦ Throughput ♦ Electron tubes
Abstract Controlled release of drugs with nanostructured capsules in microdroplets (μdroplets) using a microfluidic device is reported for the first time. Specifically, experiments demonstrated successfully that the drug release can be controlled by dynamically changing the pH of the control solution (water + NaOH) through a microfluidic chip. By observing the fluorescent images of microdroplets, it shows that the drug release inside a microdroplet environment can span from several minutes to several weeks by the control solutions of different pH. Since each microdroplet can serve as a microtiter plate, and hundreds and thousands of microdroplets can be generated rapidly, thus a controlled drug release platform with high throughput for drug screen and discovery could be potentially realized.
Description Author affiliation: Institution for Micromanufacturing, Louisiana Tech University, Ruston, LA (Yuan He; Wen-Chuan Cheng; Yafei Zhao; Lvov, Y.; Long Que)
ISBN 9781457717666
ISSN 19300395
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-10-28
Publisher Place Taiwan
Rights Holder Institute of Electrical and Electronics Engineers, Inc. (IEEE)
e-ISBN 9781457717673
Size (in Bytes) 832.70 kB
Page Count 4
Starting Page 1
Ending Page 4

Source: IEEE Xplore Digital Library