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Author Campen, A. ♦ Yuni Xia ♦ Rigsby, D. ♦ Ying Guo ♦ Xingdong Feng ♦ Su, E.W. ♦ Palakal, M. ♦ Shuyu Li
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2008
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Gene expression ♦ Databases ♦ Humans ♦ Diseases ♦ Cancer ♦ Clinical diagnosis ♦ Data analysis ♦ Testing ♦ Data mining ♦ Pipelines
Abstract Studies of gene expression in primary human disease tissue often span several years in order to achieve reasonably large sample sizes and to collect patient clinical information making this data particularly valuable. Due to the lack of a central repository, this data has only been available through disparate and non-publicly accessible sources following publication. We developed disease-to-gene expression mapper (D-GEM) as a publically accessible database and data mining toolbox for microarray data of human primary disease tissue. A statistical pipeline has also been implemented to identify genes over-expressed in disease tissue samples in comparison with normal control samples, or genes whose expression values are associated with clinical parameters such as patient survival rate. One potential application of this data is the identification of pathway specific cancer prognosis markers. By applying a novel, gene signatures for cancer prognosis in the context of known biological pathways in cancer development were identified and confirmed.
Description Author affiliation: Dept. of Comput. Sci., Indiana Univ., Indianapolis, IN (Campen, A.)
ISBN 9781424418367
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2008-04-07
Publisher Place Mexico
Rights Holder Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Size (in Bytes) 5.77 MB
Page Count 4
Starting Page 1604
Ending Page 1607


Source: IEEE Xplore Digital Library