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Author Unlu, M.S. ♦ Daaboul, G.G. ♦ Yurt, A. ♦ Lopez, C.A. ♦ Goldberg, B.B. ♦ Connor, J.H.
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2011
Language English
Subject Domain (in DDC) Technology ♦ Engineering & allied operations ♦ Applied physics
Subject Keyword Nanoparticles ♦ Optical interferometry ♦ Iris recognition ♦ Imaging ♦ Shape ♦ Iris ♦ Optical surface waves
Abstract Detection of single nanoscale particles, in particular viral pathogens, have been a challenging task with earlier efforts focusing on high-Q resonators [1,2] to overcome the sensitivity limitations of conventional optical techniques. We have developed a new biodetection technique - Interferometric Reflectance Imaging Sensor (IRIS) originally for protein microarrays [3] in multiplexed molecular diagnostics. Recently, we have demonstrated that a multi-LED discrete wavelength illumination system can substitute for the tunable laser in IRIS technology [5]. Broad spectral coverage afforded by the use of multi-color visible LEDs allow for not only a compact, battery-operated, and portable system, but also enables the use of very thin transparent layer in IRIS substrates and thus high lateral resolution imaging. To detect and size pathogens, IRIS shines light from multi-color LED sources sequentially on nanoparticles bound to the sensor surface, which consists of a silicon dioxide layer on top of a silicon substrate (see Fig. 1). Interference of light reflected from the sensor surface (acting as a planar optical antenna) is modified by the
Description Author affiliation: Photonics Center and Department of Electrical Engineering, Boston University, MA 02215, USA (Unlu, M.S.; Daaboul, G.G.; Yurt, A.; Lopez, C.A.; Goldberg, B.B.; Connor, J.H.)
ISBN 9781457708817
ISSN 21612064
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-06-26
Publisher Place Sweden
Rights Holder Institute of Electrical and Electronics Engineers, Inc. (IEEE)
e-ISBN 9781457708824
Size (in Bytes) 213.60 kB
Page Count 2
Starting Page 1
Ending Page 2


Source: IEEE Xplore Digital Library