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Author Sanchez, C. ♦ Rodriguez, B. ♦ Pueyo, E.
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2011
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science ♦ Technology ♦ Medicine & health
Subject Keyword Humans ♦ Steady-state ♦ Computational modeling ♦ Rotors ♦ Bars ♦ Drugs ♦ Heart
Abstract Current drugs used to treat atrial fibrillation (AF) often target tissue excitability (sodium channels) and refractoriness (hERG channels), but their efficacy is still modest. This study focuses on investigating new approaches to manage AF by conducting a systematic computer simulation study. The Maleckar action potential (AP) model was used to simulate human atrial cellular and tissue electrophysiology in control and AF-related electrically remodeled (AFER) conditions. Steady-state cellular AP duration (APD) and resting potential (Vrest), as well as tissue properties, such as refractory period (ERP), conduction velocity (CV) and reentrant dominant frequency (DF) were quantified for default conditions and following changes in model parameters. Results are compared to experimental data from the literature for validation. Results show the fundamental role of the $Na^{+}/K^{+}$ pump in electrophysiology and rotor dynamics in human atria through modulation of APD and ERP. IK1 controls re-entrant DF through modulation of AP, ERP and CV. Furthermore, the fast $Na^{+}$ current (INa) is key in determining DF through modulation of CV. The mechanisms underlying human atrial electrophysiological properties were qualitatively similar in control and AFER, although changes in ionic currents generally had smaller effects in AFER.
Description Author affiliation: Computational Biology Group, Oxford University Computing Laboratory, Oxford, UK (Rodriguez, B.) || Communications Technology Group, University of Zaragoza, Zaragoza, Spain (Sanchez, C.; Pueyo, E.)
ISBN 9781457706127
ISSN 02766547
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-09-18
Publisher Place China
Rights Holder Creative Commons Attribution License 2.5 (CCAL)
e-ISBN 9781457706110
Size (in Bytes) 196.05 kB
Page Count 4
Starting Page 77
Ending Page 80


Source: IEEE Xplore Digital Library