Thumbnail
Access Restriction
Subscribed

Author Halamek, J. ♦ Jurak, P. ♦ Leinveber, P. ♦ Vondra, V. ♦ Couderc, J.-P.
Sponsorship IEEE Eng. Med. Biol. Soc.
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2013
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science ♦ Technology ♦ Medicine & health
Subject Keyword Heart rate ♦ Acceleration ♦ Abstracts ♦ Computational modeling ♦ Adaptation models ♦ Correlation
Abstract The dependency of the QT interval to the previous RR intervals has been widely studied, QT/RR slope and other modeling techniques revealed individual-specific relationship. In this work we studied the relationship between QT/RR slope and a basal QTc interval in 154 healthy subjects and in 97 patients with the inherited long QT syndrome type-1 (LQT1) to provide insights into the effect of the impairment of the outwardly directed delayed rectifier potassium current on the dynamic QT-RR coupling. QT/RR slope values show strong relationship to basal QTc interval in healthy (R=0.65; p<;0.00001) and in LQT1 patients (R=0.56; p<;0.00001). The dependency of QT/RR slope on QTc is steeper in healthy (a1=0.0016 ± 0.0002) than in LQT1 (a1=0.0010 ± 0.0002), p<;0.0001. The steeper dependency on QTc in healthy preserves proper shortening of QT intervals during increased heart rate in healthy while in LQT1 patients the QT intervals does not adapt to increased heart rate sufficiently (lack of QT adaptation to heart rate acceleration). This observation is consistent with current clinical mechanism associated with the triggering of life-threatening arrhythmias in the LQTS type-1 patients.
Description Author affiliation: Inst. of Sci. Instrum., AS, Brno, Czech Republic (Halamek, J.; Jurak, P.; Vondra, V.) || ICRC, St. Anne's Univ. Hosp., Brno, Czech Republic (Leinveber, P.) || Univ. of Rochester Med. Center, Rochester, NY, USA (Couderc, J.-P.)
ISBN 9781479908844
ISSN 2325887X
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-09-22
Publisher Place Spain
Rights Holder Creative Commons Attribution License 2.5 (CCAL)
e-ISBN 9781479908868
Size (in Bytes) 416.88 kB
Page Count 4
Starting Page 65
Ending Page 68


Source: IEEE Xplore Digital Library