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Author Ye Hua ♦ Han Chun-Chun ♦ Wang Ji-Wen ♦ Li Liang
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2008
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology ♦ Biochemistry ♦ Technology ♦ Medicine & health
Subject Keyword Intestines ♦ Animals ♦ Liver ♦ Humans ♦ Muscles ♦ Biochemistry ♦ Plasmas ♦ Gene expression ♦ Blood ♦ Abdomen
Abstract 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is an essential enzyme in endogenous cholesterol synthesis, and it plays an important role in the homeostasis of cholesterol. In this study, with of Landes geese and Tianfu meat geese as the experimental objects, using RT-PCR method, the influence of overfeeding on the expression of HMGR gene in geese liver and its possible mechanism were analyzed. The results showed that the mRNA expression of HMGR gene was detected in liver, abdominal and subcutaneous adipose tissues, intestines, and muscles, while there was the highest expression level in the liver. In addition, the plasma cholesterol concentration was negatively correlated with the hepatic HMGR gene mRNA expression abundance (r=-0.559, P<0.05; r=-0.562, P<0.05). At last, the overfeeding markedly depressed HMGR mRNA abundance in liver and the degree of decrease is higher in the Tianfu meat geese.
Description Author affiliation: Key Lab. of Animal Genetic Resources, Sichuan Agric. Univ., Sichuan (Ye Hua; Han Chun-Chun; Wang Ji-Wen; Li Liang)
ISBN 9781424417476
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2008-05-16
Publisher Place China
Rights Holder Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Size (in Bytes) 203.02 kB
Page Count 4
Starting Page 318
Ending Page 321


Source: IEEE Xplore Digital Library