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Author Graff, C. ♦ Nielsen, J. ♦ Kanters, J.K. ♦ Matz, J. ♦ Schmidt, S.E. ♦ Toft, E. ♦ Struijk, J.J.
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2011
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science ♦ Technology ♦ Medicine & health
Subject Keyword Morphology ♦ Drugs ♦ Electrocardiography ♦ Educational institutions ♦ Standardization ♦ Monitoring ♦ Safety
Abstract Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.
Description Author affiliation: Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Copenhagen, Denmark (Kanters, J.K.) || H. Lundbeck A/S, Copenhagen, Denmark (Matz, J.) || Department of Health Science and Technology, Aalborg University, Aalborg, Denmark (Graff, C.; Schmidt, S.E.; Toft, E.; Struijk, J.J.) || Aalborg Psychiatric Hospital, Aarhus University Hospitals, Aalborg, Denmark (Nielsen, J.)
ISBN 9781457706127
ISSN 02766547
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-09-18
Publisher Place China
Rights Holder Creative Commons Attribution License 2.5 (CCAL)
e-ISBN 9781457706110
Size (in Bytes) 218.29 kB
Page Count 4
Starting Page 737
Ending Page 740


Source: IEEE Xplore Digital Library