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Author Xianjun Li ♦ Jie Gao ♦ Xin Hou ♦ Chan, K.C. ♦ Ding, A. ♦ Qinli Sun ♦ Mingxi Wan ♦ Wu, E.X. ♦ Jian Yang
Sponsorship IEEE Eng. Medicine Biol. Soc.
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Engineering & allied operations
Subject Keyword Diffusion tensor imaging ♦ Pediatrics ♦ Correlation ♦ Sensitivity ♦ Educational institutions ♦ Anisotropic magnetoresistance ♦ preschool children ♦ Diffusion kurtosis imaging (DKI) ♦ tract-based spatial statistics (TBSS) ♦ white matter
Abstract Diffusion kurtosis imaging (DKI), an extension of diffusion tensor imaging (DTI), provides a practical method to describe non-Gaussian water diffusion in neural tissues. The sensitivity of DKI to detect the subtle changes in several chosen brain structures has been studied. However, intuitive and holistic methods to validate the merits of DKI remain to be explored. In this paper, tract-based spatial statistics (TBSS) was used to demonstrate white matter alterations in both DKI and DTI parameters in preschool children (1-6 years; n=10). Correlation analysis was also performed in multiple regions of interest (ROIs). Fractional anisotropy, mean kurtosis, axial kurtosis and radial kurtosis increased with age, while mean diffusivity and radial diffusivity decreased significantly with age. Fractional anisotropy of kurtosis and axial diffusivity were found to be less sensitive to the changes with age. These preliminary findings indicated that TBSS could be used to detect subtle changes of DKI parameters on the white matter tract. Kurtosis parameters, except fractional anisotropy of kurtosis, demonstrated higher sensitivity than DTI parameters. TBSS may be a convenient method to yield higher sensitivity of DKI.
Description Author affiliation: Dept. of Biomed. Eng., Xi'an Jiaotong Univ., Xi'an, China (Mingxi Wan) || Dept. of Radiol., Xi'an Jiaotong Univ., Xi'an, China (Xianjun Li; Jie Gao; Xin Hou; Qinli Sun; Jian Yang) || Lab. of Biomed. Imaging & Signal Process., Univ. of Hong Kong, Hong Kong, China (Chan, K.C.; Ding, A.; Wu, E.X.)
ISBN 9781424441198
ISSN 1557170X
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-08-28
Publisher Place USA
Rights Holder Institute of Electrical and Electronics Engineers, Inc. (IEEE)
e-ISBN 9781457717871
Size (in Bytes) 852.94 kB
Page Count 4
Starting Page 2298
Ending Page 2301


Source: IEEE Xplore Digital Library