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Author Szilagyi, S.M. ♦ Szilagyi, L.
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science ♦ Technology ♦ Medicine & health
Subject Keyword Computational modeling ♦ Pathology ♦ Mathematical model ♦ Spirals ♦ Heart ♦ Nonhomogeneous media ♦ Muscles
Abstract Aims: This study focuses on the most important cardiac malfunction cases responsible for sudden cardiac death and on detailed visualization of all formation phases of the deadly, self maintaining spiral waves (SW) that may occur in the ventricular tissue and develop ventricular fibrillation (VF). Methods: We developed a spatio-temporal computerized model of the whole heart that handles half millimeter sized compartments using 1μs time step. We employed the effect of muscle fiber direction, laminar sheets, depolarization period and other parameters. In presence of ischemia, normal parameter values were no longer maintained. In our simulation the depolarization wave (DW) conduction speed of the injured-but still functioning-tissue was decreased by up to 20 times, while the chance of spontaneous ectopic-firing (SEF) was increased by up to 1000 times. Results: Under normal conditions the development probability of the SW was under 2% using 1-hour simulated period and had a 90% correlation with ventricular stimulation speed, and 75% with minimal depolarization period of the ventricular tissue. Conclusion: Large size and low conducting speed of the injured ventricular tissue and the high probability of SEF are the main generating factors of SW.
Description Author affiliation: Sapientia University of Iransylvama, Tîrgu Mureş, Romania (Szilagyi, L.) || Petru Maior University, Tîrgu Mureş, Romania (Szilagyi, S.M.)
ISBN 9781467320764
ISSN 2325887X
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-09-09
Publisher Place Poland
Rights Holder Creative Commons Attribution License 2.5 (CCAL)
e-ISBN 9781467320771
Size (in Bytes) 248.21 kB
Page Count 4
Starting Page 853
Ending Page 856


Source: IEEE Xplore Digital Library