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Author Moya, A. ♦ Illa, X. ♦ Prats-Alfonso, E. ♦ Zine, N. ♦ Gabriel, G. ♦ Errachid, A. ♦ Villa, R.
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Engineering & allied operations ♦ Applied physics
Subject Keyword Gold ♦ Microelectrodes ♦ Microfluidics ♦ Electric potential ♦ Current measurement ♦ Calibration ♦ Microfluidic ♦ Multi-sensor ♦ Lab-on-a-Chip ♦ Flexible ♦ μISE ♦ Electrochemical
Abstract A novel polymeric microfluidic multi-sensor system has been developed using rapid prototyping techniques and low-cost materials which permits the dynamic online monitoring of several cell culture parameters in a wide range of biomedical applications. The multi-sensor is made of polymeric flexible substrate with integrated gold microband electrodes for electrochemical measurements of Dissolved Oxygen (DO) and Hydrogen $(H^{+}),$ Sodium $(Na^{+})$ and Potassium $(K^{+})$ cations. The platform integrates several working electrodes (WE), pseudoreferences (pRE) and a counter electrode (CE) for electrochemical detection. The bio-lab-on-a-chip allows the detection of changes in real time, with rapid response, allowing to measure small volumes and fast cell metabolisms changes. The reliable analytical performance of the platform in in-vitro conditions has been demonstrated. DO was detected with activated gold electrode, and $H^{+},$ $Na^{+}$ and $K^{+}$ were detected with the developed ion-selective microelectrodes (μISE) using electropolymerized polypyrrole (PPy) film as a contact layer, allowing a good performance of the sensor.
Description Author affiliation: Inst. de Microelectron. de Barcelona, Barcelona, Spain (Moya, A.; Illa, X.; Prats-Alfonso, E.; Gabriel, G.; Villa, R.) || Inst. des Sci. Analytiques, Univ. Lyon, Villeurbanne, France (Zine, N.; Errachid, A.)
ISBN 9781479901623
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-11-02
Publisher Place Spain
Rights Holder Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Size (in Bytes) 1.09 MB
Page Count 4
Starting Page 1018
Ending Page 1021


Source: IEEE Xplore Digital Library