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Author Tobon, C. ♦ Cardona, K. ♦ Pandit, S.V. ♦ Jalife, J. ♦ Berenfeld, O. ♦ Saiz, J.
Sponsorship IEEE Eng. Med. Biol. Soc.
Source IEEE Xplore Digital Library
Content type Text
Publisher Institute of Electrical and Electronics Engineers, Inc. (IEEE)
File Format PDF
Copyright Year ©2013
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science ♦ Technology ♦ Medicine & health
Subject Keyword Computational modeling ♦ Abstracts ♦ Kinetic theory ♦ Protocols ♦ Mechanical factors ♦ Biological system modeling
Abstract Ionic expression gradients could determine the paroxysmal atrial fibrillation (pAF) dynamics. Recently, it has been demonstrated that the acetylcholine (ACh)-activated potassium current (IKACh) and the inward rectifier $K^{+}$ current $(I_{K1})$ densities are ≈2-fold larger in the left atrium (LA) versus right atrium (RA) during pAF, which may result in a greater increase in LA than RA rotor frequency. We investigated how the ionic expression gradients may affect the pAF dynamics. Experimental LA-RA $I_{K1}$ and $I_{KACh}$ gradients were incorporated in a cellular atrial kinetics to simulate pAF in a 3D model of the human atria. pAF episodes were generated by a burst of 6 ectopic beats. In pAF model (with $I_{K1}$ and $I_{KACh}$ gradients) action potential duration (APD) gradient was observed. However, without $I_{K1}$ gradient or without $I_{KACh}$ gradient the APD gradient was decreased. In the pAF model, single rotor and then figure-of-eight reentry sustained in the LA maintained the AF, without reentrant activity in RA. When one of the two ionic expression gradients was not present, the pAF was maintained by multiple reentrant waves that collided and fragmented in the RA. In conclusion, LA-RA gradients in both $I_{KACh}$ and $I_{K1}$ expression are important in establishing APD and frequency gradients, and LA reentrant activity maintaining pAF.
Description Author affiliation: GI2B, Inst. Tecnol. Metropolitano, Medellin, Colombia (Tobon, C.) || Center for Arrhythmia Res., Univ. of Michigan, Ann Arbor, MI, USA (Pandit, S.V.; Jalife, J.; Berenfeld, O.) || I3BH, Univ. Politec. de Valencia, Valencia, Spain (Cardona, K.; Saiz, J.)
ISBN 9781479908844
ISSN 2325887X
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research ♦ Reading
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-09-22
Publisher Place Spain
Rights Holder Creative Commons Attribution License 2.5 (CCAL)
e-ISBN 9781479908868
Size (in Bytes) 1.23 MB
Page Count 4
Starting Page 1063
Ending Page 1066


Source: IEEE Xplore Digital Library