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Author Stokes, Gordon S. ♦ Weber, Michael A.
Source British Medical Journal (The BMJ)
Content type Text
Publisher British Medical Journal Publishing Group
File Format HTM / HTML
Language English
Abstract In a group of 14 hypertensive patients a 10-week course of treatment with prazosin 3-7·5 mg/day produced a significant reduction in mean blood pressure without serious side effects. The fall in diastolic pressure exceeded the response to a placebo by 10 mm Hg or more in 9 patients. The average decrease in diastolic pressure was similar to that produced by methyldopa 750 mg/day or propranolol 120-160 mg/day but the fall in systolic pressure was comparatively smaller, consistent with reported experimental work showing that the drug causes vasodilatation. The hypotensive effect of prazosin 1·5-3 mg/day combined with propranolol was significantly greater than that of propranolol alone and resulted in good control of blood pressure.
Description Citation Reference: British Medical Journal
ISSN 00071447
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Learning Resource Type Article
Publisher Date 1974-05-11
e-ISSN 14685833
Journal British Medical Journal (The BMJ)
Volume Number 2
Issue Number 5914
Page Count 3
Starting Page 298
Ending Page 300


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Source: British Medical Journal (The BMJ)