Access Restriction

Author Wondergem, Maurits ♦ Zant, Friso M. Van Der ♦ Knol, Remco J. J. ♦ Pruim, Jan ♦ Jong, Igle J. De
Source Paperity
Content type Text
Publisher Springer Berlin Heidelberg
File Format PDF ♦ HTM / HTML
Copyright Year ©2016
Subject Keyword Orthopedics ♦ Cardiology ♦ Oncology ♦ Nuclear medicine ♦ Imaging / radiology
Abstract Background 18F-fluorocholine PET/CT is used to detect lymph node metastases in prostate cancer patients. Physiological 18F-fluorocholine in the gastrointestinal tract, especially in the intestines, may interfere with the detection of malignant lymph nodes. Fasting is frequently proposed in literature; however, scientific support is lacking. This study aims to determine the impact of fasting on 18F-fluorocholine uptake in the gastrointestinal tract. Methods Eighty patients were studied, 40 fasted for at least 6 h prior to 18F-fluorocholine administration while the other 40 did not fast. 18F-fluorocholine uptake pattern and intensity were evaluated in the intestine near the abdominal aorta and four regions near the iliac arteries. 18F-fluorocholine intensity was also measured in the liver, pancreas, stomach and spleen. Findings No statistically significant differences were found in 18F-fluorocholine uptake in the gastrointestinal tract between the fasting and non-fasting group. Conclusions Fasting for 6 h has no effect on 18F-fluorocholine uptake in the gastrointestinal tract. Therefore, no effects on the detection of malignant lymph nodes are expected, and fasting is not recommended in our opinion.
Learning Resource Type Article
Publisher Date 2016-12-01
e-ISSN 2191219X
Journal EJNMMI Research
Volume Number 6
Issue Number 1