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Author Farzan, Shohreh F. ♦ Karagas, Margaret R. ♦ Jiang, Jieying ♦ Wu, Fen ♦ Liu, Mengling ♦ Newman, Jonathan D. ♦ Jasmine, Farzana ♦ Kibriya, Muhammad G. ♦ Paul-Brutus, Rachelle ♦ Parvez, Faruque ♦ Argos, Maria ♦ Bryan, Molly Scannell ♦ Eunus, Mahbub ♦ Ahmed, Alauddin ♦ Islam, Tariqul ♦ Rakibuz-Zaman, Muhammad ♦ Hasan, Rabiul ♦ Sarwar, Golam ♦ Slavkovich, Vesna ♦ Graziano, Joseph
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ARSENIC ♦ BLOOD ♦ BLOOD PRESSURE ♦ CARDIOVASCULAR DISEASES ♦ CHEMICAL VAPOR DEPOSITION ♦ DISEASE INCIDENCE ♦ GENES ♦ GENETIC VARIABILITY ♦ GENETICS ♦ GENOTYPE ♦ HEALTH HAZARDS
Abstract Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and mounting evidence indicates that toxicant exposures can profoundly impact on CVD risk. Epidemiologic studies have suggested that arsenic (As) exposure is positively related to increases in blood pressure (BP), a primary CVD risk factor. However, evidence of whether genetic susceptibility can modify the association between As and BP is lacking. In this study, we used mixed effect models adjusted for potential confounders to examine the interaction between As exposure from well water and potential genetic modifiers on longitudinal change in BP over approximately 7 years of follow-up in 1137 subjects selected from the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Bangladesh. Genotyping was conducted for 235 SNPs in 18 genes related to As metabolism, oxidative stress and endothelial function. We observed interactions between 44 SNPs with well water As for one or more BP outcome measures (systolic, diastolic, or pulse pressure (PP)) over the course of follow-up. The interaction between CYBA rs3794624 and well water As on annual PP remained statistically significant after correction for multiple comparisons (FDR-adjusted p for interaction = 0.05). Among individuals with the rs3794624 variant genotype, well water As was associated with a 2.23 mm Hg (95% CI: 1.14–3.32) greater annual increase in PP, while among those with the wild type, well water As was associated with a 0.13 mm Hg (95% CI: 0.02–0.23) greater annual increase in PP. Our results suggest that genetic variability may contribute to As-associated increases in BP over time. - Highlights: • Arsenic (As) exposure has been associated with blood pressure increases over time. • Genetic polymorphisms may modify the association between As and blood pressure. • An interaction between CYBA rs3794624 and well As increased annual pulse pressure. • Genetic variants may contribute to As-related blood pressure increases over time.
ISSN 0041008X
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-10-01
Publisher Place United States
Journal Toxicology and Applied Pharmacology
Volume Number 288
Issue Number 1


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