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Author Delage, M. ♦ Cloutier, E. ♦ Lecavalier, M. ♦ Lariviere, D. ♦ Allen, C. ♦ Beaulieu, L.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ RADIATION PROTECTION AND DOSIMETRY ♦ BIOLOGICAL RADIATION EFFECTS ♦ BIOMEDICAL RADIOGRAPHY ♦ CADMIUM SELENIDES ♦ ENERGY DEPENDENCE ♦ IONIZING RADIATIONS ♦ MATERIALS RECOVERY ♦ PHOTOLUMINESCENCE ♦ QUANTUM DOTS ♦ RADIATION DOSES ♦ RADIOLUMINESCENCE ♦ RADIOTHERAPY ♦ ZINC SULFIDES
Abstract Purpose: This study intends to characterize the energy dependence of the effect of radiation damage on CdSe multi-shell (MS) (CdS/CdZnS/ZnS) and CdSe core/shell (CS)(ZnS) cQDs. It also aims to investigate irregularities resulting of pauses between subsequent irradiations. Methods: Radioluminescence (RL) measurements were performed with a CCD camera as dose was cumulated by the cQDs (up to 10 kGy), for beam energies 120 kVp, 220 kVp and 6 MV. Repeated expositions of 1999 MU were cumulated. Pauses between subsequent irradiations were varied from 2 to 50 minutes. cQDs photoluminescence (PL) and RL spectral stability was tracked by quantifying the position and FWHM of the luminescence peak. Results: Both types of cQDs showed a clear energy dependence of the RL signal decrease between the kV and the MV beams. For 1.2 kGy of dose cumulated, MS cQDs had 92% of the initial signal left at 6 MV compared to 98% at 120 kVp. The same was observed for CS cQDs: 87% at 6 MV vs 94% at 120 kVp. MS cQDs were found to have a systematic (though small, ∼1%) RL intensity recovery for pauses of 15 minutes or more, while CS cQDs maintain a stable loss regardless of the pause duration. PL and RL spectral measurements revealed a good stability (< 1% variation of the peak position and FWHM) for both types of cQDs. Conclusion: In all, both MS and CS cQDs have a sufficient resistance to large doses of radiation for standard radiation therapy and imaging. Since this resistance is better for lower energy, the utilization of cQDs could be optimized for low energy applications (e.g. theragnostic applications for small animal studies and others). Finally, the ionizing radiation damage mechanisms for this new type of nano-scintillator still have to be identified properly.
ISSN 00942405
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-06-15
Publisher Place United States
Journal Medical Physics
Volume Number 43
Issue Number 6


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