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Author Dewey, D. L. ♦ Hawes, C.
Sponsorship USDOE
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BIOLOGY AND MEDICINE ♦ AMINES ♦ CANCER ♦ CHROMOSOMES ♦ CULTURES ♦ CYTOLOGY ♦ EFFICIENCY ♦ EHRLICH ASCITES ♦ FETUSES ♦ LIVER ♦ MAN ♦ MITOSIS ♦ PLATING ♦ RADIATION EFFECTS ♦ RADIOSENSITIVITY ♦ VITAMIN PP ♦ VITAMINS ♦ X RADIATION
Abstract The effects of 6-aminonicotinamide on the radiosensitivity of human foetal liver cells and Ehrlich ascites tumor cells were studied using x rays in separate experiments. 6-Aminonicotinamide was found to have a sensitizing effect on the radiosensitivity of liver cells when measured by reproductive integrity, but none when measured by chromosome damage; no effect was observed ih the chromosome damage in tumor cells. The reproduction and chromosome experiments differed from each other in that 6-aminonicotinsmide was added before the cells were allowed to attach to glass in the former, while the order was reversed in the latter. It is concluded that 6-aminonicotinamide reduces the plating efficiency. (D.L.C.)
Educational Use Research
Learning Resource Type Article
Publisher Date 1963-12-21
Publisher Department Mount Vernon Hospital, Northwood, Middx., Eng.
Journal Nature
Volume Number 200
Organization Mount Vernon Hospital, Northwood, Middx., Eng.


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