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Author Katherine, Tarlock ♦ Alonzo, Todd A. ♦ Moraleda, Pilar Palomo ♦ Gerbing, Robert B. ♦ Raimondi, Susana C. ♦ Hirsch, Betsy A. ♦ Ravindranath, Yaddanapudi ♦ Lange, Beverly ♦ Woods, William G. ♦ Gamis, Alan S. ♦ Meshinchi, Soheil
Source PubMed Central
Content type Text
File Format PDF
Date Created 2014-03-25
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Keyword Hematology
Abstract Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (p>0.9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.
ISSN 00071048
Age Range above 22 year
Educational Use Research
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-07-01
e-ISSN 13652141
Journal British journal of haematology
Volume Number 166
Issue Number 2
Page Count 6
Starting Page 254
Ending Page 259

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Source: PubMed Central