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Author Jiang, Chunyu ♦ Wang, Jianbo ♦ Wang, Yonggang ♦ Zhao, Jungong ♦ Zhu, Yueqi ♦ Ma, Xu ♦ Zhou, Jia ♦ Yan, Xuebing
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ ANIMAL TISSUES ♦ BIOMEDICAL RADIOGRAPHY ♦ HAZARDS ♦ MULTIVARIATE ANALYSIS ♦ PAIN ♦ PATIENTS ♦ PVA ♦ SARCOMAS ♦ SKELETON ♦ SURGERY ♦ WHO
Abstract PurposeTransarterial chemoembolization (TACE) is used to treat unresectable bone and soft tissue sarcoma (STS) and as a pre-surgical adjuvant treatment. However, its efficiency for advanced STS is undetermined. This study evaluated TACE’s efficiency in treating advanced STS and prognostic factors for patient survival.Materials and MethodsWe enrolled 39 patients with unresectable STS who underwent TACE as an alternative treatment during 2010–2014, with overall survival (OS) as the primary end point. Cancer pain was evaluated by visual analogue scores (VAS) before and after TACE procedures. Factors that affect survival were evaluated by multivariate analyses (Cox proportional hazard model).ResultsMean OS after TACE was 23.7 ± 2.1 months, with 1-year OS 71.5 %, 2-year OS 45.8 %, and 3-year OS 32.5 %. Lesion number and tumor stage were key predictors of survival. TACE was found to decrease cancer pain VAS and increase relapse interval. Size of polyvinyl alcohol (PVA) particle diameter (P = 0.03) and imaging response (P = 0.044) were also found to affect relapse interval.ConclusionTACE was an effective treatment for advanced STS, with a 32.5 % 3-year OS rate, and led to lower cancer pain VAS and longer relapse intervals than chemoinfusion only. Smaller PVA particles are preferable during the TACE procedure.
ISSN 01741551
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-10-15
Publisher Place United States
Journal Cardiovascular and Interventional Radiology
Volume Number 39
Issue Number 10


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