Thumbnail
Access Restriction
Open

Author Leuba, Sanford H. ♦ Zlatanova, Jordanka
Source J-STAGE
Content type Text
Publisher International Society of Histology and Cytology
Language English
Abstract With the advent of single-molecule techniques, macromolecular science has reached new horizons. Nowadays, we can observe, touch, stretch and twist biological macromolecules or their complexes, one-at-a time, in attempts to better understand their mechanical properties and to gain insights into their behavior in the living cell. Chromatin structure and function has been the focus of our research interests for many years. In the past decade, we have added some of the newly emerged single-molecule approaches to the more traditional biochemical and biophysical methods that we have been using throughout the years. This paper briefly summaries our studies on individual chromatin fibers using the atomic force microscope (AFM), optical tweezers, and magnetic tweezers. We believe that our results so far have contributed significantly to our understanding of chromatin, but we also hope that this is only the beginning, and that more exciting times lie ahead.
ISSN 09149465
Learning Resource Type Article
Publisher Date 2002-01-01
e-ISSN 13491717
Journal Archives of Histology and Cytology(aohc)
Volume Number 65
Issue Number 5
Page Count 13
Starting Page 391
Ending Page 403


Open content in new tab

   Open content in new tab