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Author Gomaa, Asmaa Ibrahim ♦ Ehsan, Nermine Ahmed ♦ Elrefaei, Ahmed A. ♦ Sultan, Mervat Mohamed ♦ Elsabaawy, Maha Mohamed
Editor Reale, Marcella
Source Hindawi
Content type Text
Publisher Hindawi
File Format PDF
Copyright Year ©2018
Language English
Abstract Objective. Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently. Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation. Methods. Twenty-nine cases of recurrent hepatitis C and 26 cases of ACR were included in this study. The expression of CD 68 (macrophage marker), CD11b (BDM marker), and CxCR3 in the postliver transplant biopsy using immunohistochemistry was determined. Results. CD11b expression highlighting macrophages of BDM origin was in favor of recurrent hepatitis C (P<0.001) than in ACR (P=0.44), while CXCR3 expression by hepatocytes was in favor of ACR (P=0.001). Conclusion. Macrophage infiltrating liver tissue post LT can distinguish between ACR by upregulation of CXCR3 and recurrent hepatitis C by predominant CD11b.
ISSN 23148861
Learning Resource Type Article
Publisher Date 2018-04-30
Rights License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
e-ISSN 23147156
Journal Journal of Immunology Research
Volume Number 2018
Page Count 7