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Author Kovář, David ♦ Malá, Aneta ♦ Mlčochová, Jitka ♦ Kalina, Michal ♦ Fohlerová, Zdenka ♦ Hlaváček, Antonín ♦ Farka, Zdeněk ♦ Skládal, Petr ♦ Starčuk, Zenon ♦ Jiřík, Radovan ♦ Slabý, Ondřej ♦ Hubálek, Jaromír
Editor Morais, Paulo Cesar
Source Hindawi
Content type Text
Publisher Hindawi
File Format PDF
Copyright Year ©2017
Language English
Abstract Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe.
ISSN 16874110
Learning Resource Type Article
Publisher Date 2017-02-23
Rights License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
e-ISSN 16874129
Journal Journal of Nanomaterials
Volume Number 2017
Page Count 8


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