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Author Xie, Changming ♦ Ouyang, Liu ♦ Chen, Jie ♦ Zhang, Huanji ♦ Luo, Pei ♦ Wang, Jingfeng ♦ Huang, Hui ♦ {"id":"U63532945","contrib_type":"Guest Editor","orcid":"http://orcid.org/0000-0001-8599-7441","surname":"Sotiropoulos","given-names":"Athanassia"}
Source Hindawi
Content type Text
Publisher Hindawi
File Format PDF
Copyright Year ©2019
Language English
Abstract Vascular calcification (VC), characterized by hydroxyapatite crystal depositing in the vessel wall, is a common pathological condition shared by many chronic diseases and an independent risk factor for cardiovascular events. Recently, VC is regarded as an active, dynamic cell-mediated process, during which calcifying cell transition is critical. Mesenchymal stem cells (MSCs), with a multidirectional differentiation ability and great potential for clinical application, play a duplex role in the VC process. MSCs facilitate VC mainly through osteogenic transformation and apoptosis. Meanwhile, several studies have reported the protective role of MSCs. Anti-inflammation, blockade of the BMP2 signal, downregulation of the Wnt signal, and antiapoptosis through paracrine signaling are possible mechanisms. This review displays the evidence both on the facilitating role and on the protective role of MSCs, then discusses the key factors determining this divergence.
ISSN 1687966X
Learning Resource Type Article
Publisher Date 2019-04-01
Rights License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
e-ISSN 16879678
Journal Stem Cells International
Volume Number 2019
Page Count 11


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