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Author Jiang, Qian ♦ Chen, Jiashun ♦ Yang, Chengbo ♦ Yin, Yulong ♦ Yao, Kang ♦ {"id":"U62109385","contrib_type":"Guest Editor","orcid":"http://orcid.org/0000-0001-5251-4116","surname":"Song","given-names":"Deguang"}
Source Hindawi
Content type Text
Publisher Hindawi
File Format PDF
Copyright Year ©2019
Language English
Abstract Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases.
ISSN 23146133
Learning Resource Type Article
Publisher Date 2019-04-04
Rights License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
e-ISSN 23146141
Journal BioMed Research International
Volume Number 2019
Page Count 15