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Author Posadas-Sánchez, Rosalinda ♦ Pérez-Hernández, Nonanzit ♦ Angeles-Martínez, Javier ♦ López-Bautista, Fabiola ♦ Villarreal-Molina, Teresa ♦ Rodríguez-Pérez, José Manuel ♦ Fragoso, José Manuel ♦ Posadas-Romero, Carlos ♦ Vargas-Alarcón, Gilberto
Editor Tsuji, Fumio
Source Hindawi
Content type Text
Publisher Hindawi
File Format PDF
Copyright Year ©2017
Language English
Abstract Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individuals. The IL-12A and EBI3 polymorphisms were determined in 1162 patients with premature CAD and 873 controls. Under different models, the EBI3 rs428253 (OR = 0.831, P a d d = 0.036; OR = 0.614, P r e c = 0.033; OR = 0.591, P c o d 2 = 0.027) and IL-12A rs2243115 (OR = 0.674, P a d d = 0.010; OR = 0.676, P d o m = 0.014; OR = 0.698, P h e t = 0.027; OR = 0.694, P c o d 1 = 0.024) polymorphisms were associated with decreased risk of developing premature CAD. Some polymorphisms were associated with clinical and metabolic parameters. Significant different levels of IL-35 were observed in EBI3 rs4740 and rs4905 genotypes only in the group of healthy controls. In summary, our study suggests that the EBI3 and IL-12A polymorphisms play an important role in decreasing the risk of developing premature CAD; it also demonstrates the relationship of the EBI3 rs4740 and rs4905 genotypes with IL-35 levels in healthy individuals.
ISSN 09629351
Learning Resource Type Article
Publisher Date 2017-02-22
Rights License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
e-ISSN 14661861
Journal Mediators of Inflammation
Volume Number 2017
Page Count 10


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