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Author Ge, Zhenyang ♦ Duan, Zhijun ♦ Yang, Hang ♦ Zhang, Shengai ♦ Zhang, Shuang ♦ Wang, Lixia ♦ Yang, Dong ♦ Sun, Xiaoyu ♦ Zhang, Zhifeng ♦ Su, Liping ♦ Zhu, Hong ♦ Zhou, Dongdong ♦ Liu, Bojia ♦ Shi, Honggang ♦ Yu, Jun ♦ Yang, Hui ♦ Chang, Qingyong ♦ Zhang, Nina ♦ Wu, Dongsheng ♦ Chen, Jiande D. Z.
Editor Bashir, Samra
Source Hindawi
Content type Text
Publisher Hindawi
File Format PDF
Copyright Year ©2018
Language English
Abstract This study aims to investigate the role of transcutaneous neuromodulation (TN) on the regulation of gastrointestinal hormones and bile acids in patients with functional constipation (FC). Twenty FC patients were treated with TN for four weeks. The effects of TN on symptoms were evaluated by questionnaires. Plasma levels of serotonin (5-HT), motilin, somatostatin, and vasoactive intestinal peptide (VIP) were measured by ELISA and 12 individual bile acids assayed by liquid chromatography tandem mass spectrometry. Results were as follows. (1) TN treatment increased the frequency of spontaneous bowel movement, improved the Bristol Stool Score, and reduced Patient Assessment of Constipation Symptom score and Patient Assessment of Constipation Quality of Life score. (2) FC patients showed decreased plasma levels of 5-HT, motilin, and VIP and an increased plasma level of somatostatin (P<0.05). Four-week TN treatment increased plasma levels of 5-HT and motilin and decreased the plasma level of somatostatin in the FC patients (P<0.05). (3) Taurocholic deoxycholate, taurocholic acid, and taurocholic lithocholic acid were increased in the FC patients (P<0.005) but reduced by TN treatment (P<0.05). This study has suggested that the therapy may improve the symptoms of FC by alleviating the disorders of gastrointestinal hormones and bile acids.
ISSN 1741427X
Learning Resource Type Article
Publisher Date 2018-04-29
Rights License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
e-ISSN 17414288
Journal Evidence-Based Complementary and Alternative Medicine
Volume Number 2018
Page Count 12


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