Thumbnail
Access Restriction
Open

Author Maiellaro, Marília ♦ Correa-Costa, Matheus ♦ Vitoretti, Luana Beatriz ♦ Gimenes Júnior, João Antônio ♦ Câmara, Niels Olsen Saraiva ♦ Tavares-de-Lima, Wothan ♦ Farsky, Sandra Helena Poliselli ♦ Lino-dos-Santos-Franco, Adriana
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ANTIBODIES ♦ ASTHMA ♦ FORMALDEHYDE ♦ INFLAMMATION ♦ LUNGS ♦ LYMPHOKINES ♦ OVA ♦ OVALBUMIN ♦ OXIDATION ♦ PARTURITION ♦ POLLUTANTS ♦ PREGNANCY ♦ PROGENY ♦ RATS ♦ SECRETION ♦ STRESSES ♦ SYNTHESIS ♦ TOXICITY ♦ UTERUS ♦ WATER
Abstract Formaldehyde (FA) is an environmental and occupational pollutant, and its toxic effects on the immune system have been shown. Nevertheless, no data are available regarding the programming mechanisms after FA exposure and its repercussions for the immune systems of offspring. In this study, our objective was to investigate the effects of low-dose exposure of FA on pregnant rats and its repercussion for the development of allergic lung inflammation in offspring. Pregnant Wistar rats were assigned in 3 groups: P (rats exposed to FA (0.75 ppm, 1 h/day, 5 days/week, for 21 days)), C (rats exposed to vehicle of FA (distillated water)) and B (rats non-manipulated). After 30 days of age, the offspring was sensitised with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1%, 15 min, 3 days). After 24 h the OVA challenge the parameters were evaluated. Our data showed that low-dose exposure to FA during pregnancy induced low birth weight and suppressed the development of allergic lung inflammation and tracheal hyperresponsiveness in offspring by mechanisms mediated by reduced anaphylactic antibodies synthesis, IL-6 and TNF-alpha secretion. Elevated levels of IL-10 were found. Any systemic alteration was detected in the exposed pregnant rats, although oxidative stress in the uterine environment was evident at the moment of the delivery based on elevated COX-1 expression and reduced cNOS and SOD-2 in the uterus. Therefore, we show the putative programming mechanisms induced by FA on the immune system for the first time and the mechanisms involved may be related to oxidative stress in the foetal microenvironment. - Highlights: • Formaldehyde exposure does not cause lung inflammation in pregnant rats. • Formaldehyde exposure suppresses allergic lung inflammation in the offspring. • Formaldehyde exposure induces oxidative stress in uterine environment.
ISSN 0041008X
Educational Use Research
Learning Resource Type Article
Publisher Date 2014-08-01
Publisher Place United States
Journal Toxicology and Applied Pharmacology
Volume Number 278
Issue Number 3


Open content in new tab

   Open content in new tab