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Author Guarino, Vincenzo ♦ Altobelli, Rosaria ♦ Cirillo, Valentina ♦ Ambrosio, Luigi
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ALGINATES ♦ ANIMAL TISSUES ♦ BIOLOGICAL MATERIALS ♦ DELIVERY ♦ DRUGS ♦ ELECTROSTATICS ♦ FIBERS ♦ IN VITRO ♦ IN VIVO ♦ NANOSTRUCTURES ♦ POLYMERS ♦ POLYSACCHARIDES ♦ PROTEINS ♦ THREE-DIMENSIONAL LATTICES
Abstract A large variety of processes and tools is continuously investigated to discover new solutions to design instructive materials with controlled chemical, physical and biological properties for tissue engineering and drug delivery. Among them, electro fluido dynamic techniques (EFDTs) are emerging as an interesting strategy, based on highly flexible and low-cost processes, to revisit old biomaterial’s manufacturing approach by utilizing electrostatic forces as the driving force for the fabrication of 3D architectures with controlled physical and chemical functionalities to guide in vitro and in vivo cell activities. By a rational selection of polymer solution properties and process conditions, EFDTs allow to produce fibres and/or particles at micro and/or nanometric size scale which may be variously assembled by tailored experimental setups, thus giving the chance to generate a plethora of different 3D devices able to incorporate biopolymers (i.e., proteins, polysaccharides) or active molecules (e.g., drugs) for different applications. Here, we focus on the optimization of basic EFDTs - namely electrospinning, electrospraying and electrodynamic atomization - to develop active platforms (i.e., monocomponent, protein and drug loaded scaffolds and µ-scaffolds) made of synthetic (PCL, PLGA) or natural (chitosan, alginate) polymers. In particular, we investigate how to set materials and process parameters to impart specific morphological, biochemical or physical cues to trigger all the fundamental cell–biomaterial and cell– cell cross-talking elicited during regenerative processes, in order to reproduce the complex microenvironment of native or pathological tissues.
ISSN 0094243X
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-12-17
Publisher Place United States
Volume Number 1695
Issue Number 1


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