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Author Kojima, S. ♦ Kurihara, T. ♦ Yamawaki, T. ♦ Kjellstroem, T.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ BASIC BIOLOGICAL SCIENCES ♦ CADMIUM ♦ BIOLOGICAL EFFECTS ♦ BODY BURDEN ♦ AGE DEPENDENCE ♦ DOSE-RESPONSE RELATIONSHIPS ♦ EPIDEMIOLOGY ♦ EXCRETION ♦ FECES ♦ FOOD ♦ GLOBULINS ♦ INTAKE ♦ JAPAN ♦ KIDNEYS ♦ MAN ♦ PROTEINS ♦ QUANTITY RATIO ♦ URINE ♦ ANIMALS ♦ ASIA ♦ BIOLOGICAL MATERIALS ♦ BIOLOGICAL WASTES ♦ BODY ♦ BODY FLUIDS ♦ CLEARANCE ♦ ELEMENTS ♦ MAMMALS ♦ METALS ♦ ORGANIC COMPOUNDS ♦ ORGANS ♦ PRIMATES ♦ VERTEBRATES ♦ WASTES 560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987) ♦ Metabolism
Abstract A study was made of 156 farmers living in a cadmium-exposed area and 93 farmers in a reference area. All were between 50 and 69 years of age. Cadmium intake from food was estimated from daily fecal cadmium content, body burden from urinary cadmium concentration, and cadmium-induced renal effects from urinary ..beta../sub 2/-microglobulin (..beta../sub 2/-m) and total protein concentration. Average cadmium intake in the reference area was about 40 ..mu..g/day and in the exposed area about 150 ..mu..g/day. Average urinary cadmium excretion in the reference group was 2 ..mu..g/liter and in the exposed group 7.5 ..mu..g/liter. Average urinary ..beta../sub 2/-m concentration in the reference group was 86 ..mu..g/liter and we defined tubular proteinuria as a ..beta../sub 2/-m concentration higher than the average plus two standard deviations. With this definition the prevalence rate of tubular proteinuria was 3 percent in the reference group and 14 percent in the exposed group. Tubular proteinuria increased with age and with exposure duration. Increased total proteinuria was also more common in the exposed group but the prevalence rate ratio was 2.4 as compared to 4.4 for tubular proteinuria.
Educational Use Research
Learning Resource Type Article
Publisher Date 1977-12-01
Publisher Place United States
Journal Environ. Res.
Volume Number 14
Issue Number 3


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