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Author Hoet, Armando E. ♦ Saif, Linda J.
Source Cambridge University Press (CUP) [COVID-19]
Content type Text
Language English
Subject Keyword Bovine torovirus ♦ Breda virus ♦ Epidemiology
Abstract Bovine torovirus (BoTV) is a pleomorphic virus with a spike-bearing envelope and a linear, non-segmented, positive-sense single-stranded RNA genome. This kidney-shaped virus is associated with diarrhea in calves and apparently has a worldwide distribution. This review provides details of the history and taxonomy of BoTV since its discovery in 1979. Information about virion morphology and architecture, antigenic and biological properties, viral genome, protein composition, thermal and chemical stability, and pH and proteolytic enzymes resistance is also summarized. A major focus of this review is to postulate a possible epidemiological cycle for BoTV, based on epidemiological data obtained in our studies and other published data, and progressing from the newborn calf to the adult animal. The distribution, host range, pathogenesis, disease and clinical signs (under experimental and natural exposure), pathology, diagnosis, prevention, treatment and control of BoTV infections are also described. In addition, a discussion of the zoonotic implications of torovirus-like particles detected in patients with gastroenteritis that resemble and cross-react with BoTV is presented. Hopefully, the findings described here will alert others to the existence of BoTV in cattle and its contribution to the diarrheal disease complex. This review also highlights the need for continual vigilance for potential zoonotic viruses belonging to the order Nidovirales, such as the SARS coronavirus.
Description Bovine torovirus (Breda virus) revisited - Volume 5 Issue 2 - Armando E. Hoet, Linda J. Saif
Educational Role Student ♦ Teacher
Educational Use Research
Learning Resource Type Article
Publisher Date 2007-02-28
Publisher Institution Ohio State University
Journal Animal Health Research Reviews
Volume Number 5
Issue Number 2
Page Count 15
Starting Page 157
Ending Page 171