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Author Zhao, Yang ♦ Xu, Tao ♦ Chakrabarty, Krishnendu
Source ACM Digital Library
Content type Text
Publisher Association for Computing Machinery (ACM)
File Format PDF
Copyright Year ©2010
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Error recovery ♦ Biochips ♦ Microfluidics ♦ Synthesis
Abstract Recent advances in digital microfluidics have led to tremendous interest in miniaturized lab-on-chip devices for biochemical analysis. Synthesis tools have also emerged for the automated design of lab-on-chip from the specifications of laboratory protocols. However, none of these tools consider control flow or address the problem of recovering from fluidic errors that can occur during on-chip bioassay execution. We present a synthesis method that incorporates control paths and an error-recovery mechanism in the design of a digital microfluidic lab-on-chip. Based on error-propagation estimates, we determine the best locations for fluidic checkpoints during biochip synthesis. A microcontroller coordinates the implementation of the control-flow-based bioassay by intercepting the synthesis results that are mapped to the software programs. Real-life bioassay applications are used as case studies to evaluate the proposed design method. For a representative protein assay, compared to a baseline chip design, the biochip with a control path can reduce the completion time by 30% when errors occur during the implementation of the bioassay.
ISSN 15504832
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2010-08-01
Publisher Place New York
e-ISSN 15504840
Journal ACM Journal on Emerging Technologies in Computing Systems (JETC)
Volume Number 6
Issue Number 3
Page Count 28
Starting Page 1
Ending Page 28


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Source: ACM Digital Library