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Author Thiruselvam, Viswanathan ♦ Kumarevel, Thirumananseri ♦ Karthe, Ponnuraj ♦ Kuramitsu, Seiki ♦ Yokoyama, Shigeyuki ♦ Ponnuswamy, Mondikalipudur Nanjappagounder
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY ♦ APPLIED LIFE SCIENCES ♦ CRYSTAL STRUCTURE ♦ CRYSTALS ♦ MONOMERS ♦ PROTEINS ♦ RESOLUTION ♦ SYNCHROTRON RADIATION ♦ SYNCHROTRONS ♦ TOPOLOGY
Abstract The crystal structure of a hypothetical protein MJ0366, derived from Methanocaldococcus jannaschii was solved at 1.9 Å resolution using synchrotron radiation. MJ0366 was crystallized as a monomer and has knot structural arrangement. Intriguingly, the solved structure consists of novel ‘KNOT’ fold conformation. The 3{sub 1} trefoil knot was observed in the structure. The N-terminal and C-terminal ends did not participate in knot formation. - Highlights: • Crystal structure of a hypothetical protein from Methanocaldococcus jannaschii was determined. • The protein adopts novel knot fold conformation. • Structure of the first smallest knot protein was solved.
ISSN 0006291X
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-01-08
Publisher Place United States
Journal Biochemical and Biophysical Research Communications
Volume Number 482
Issue Number 2


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