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Author He, Xinlong ♦ Zou, Yunyun ♦ Yoon, Won-Byong ♦ Park, Sung-Jin ♦ Park, Dong-Sik ♦ Ahn, Juhee
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Elsevier
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Philosophy & psychology ♦ Psychology ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Microorganisms, fungi & algae ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Incidence & prevention of disease ♦ Pharmacology and therapeutics ♦ Diseases ♦ Chemical engineering
Subject Domain (in MeSH) Cells ♦ Anatomy ♦ Eukaryota ♦ Bacteria ♦ Organisms ♦ Organic Chemicals ♦ Heterocyclic Compounds ♦ Enzymes and Coenzymes ♦ Complex Mixtures ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Psychological Phenomena and Processes ♦ Psychiatry and Psychology ♦ Physical Phenomena ♦ Chemical Phenomena ♦ Physiological Phenomena ♦ Biological Sciences
Subject Keyword Discipline Biomedical Engineering ♦ Discipline Microbiology ♦ Codonopsis ♦ Chemistry ♦ Fermentation ♦ Plant Extracts ♦ Pharmacology ♦ Probiotics ♦ Animals ♦ Anti-infective Agents ♦ Bifidobacterium ♦ Metabolism ♦ Cognition ♦ Drug Effects ♦ Enzyme Inhibitors ♦ Flavonoids ♦ Analysis ♦ Free Radical Scavengers ♦ Glycoside Hydrolase Inhibitors ♦ Hek293 Cells ♦ Humans ♦ Hydroxybenzoates ♦ Lactobacillus Rhamnosus ♦ Male ♦ Mice ♦ Mice, Inbred Icr ♦ Monophenol Monooxygenase ♦ Antagonists & Inhibitors ♦ Phenols ♦ Toxicity ♦ Pressure ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract This study was designed to evaluate the enhancement of antioxidant, antimicrobial, enzymatic, cytotoxic, and cognitive activities of Codonopsis lanceolata extracted by high pressure treatment followed by probiotic fermentation. Dried C. lanceolata samples were subjected to 400 MPa for 20 min and then fermented with Bifidobacterium longum B6 (HPE-BLF) and Lactobacillus rhamnosus (HPE-LRF) at 37 °C for 7 days. Compared to conventional extraction (CE-NF, 6.69 mg GAE/g), the phenol amounts of HPE-BLF and HPE-LRF were significantly increased to more than 8 mg GAE/g, while the lowest flavonoid contents were observed for HPE-BLF (0.44 mg RE/mL) and HPE-LRF (0.45 mg RE/mL) (p<0.05). Cinnamic acid was the most abundant phenolic acid in the fermented C. lanceolata. The highest DPPH scavenging activities were observed for HPE-BLF and HPE-LRF, with minimum EC(50) values of 1.26 and 1.18 mg/mL, respectively. The HPE-BLF and HPE-LRF samples exhibited the most noticeable antimicrobial activities against Staphylococcus aureus, Listeria monocytogenes, Salmonella Typhimurium, and Shigella boydii (MICs<15 mg/mL). The fermented C. lanceolata samples effectively inhibited -glucosidase and tyrosinase activities and potentially improved a scopolamine-induced memory deficit in mice. The application of a fermentation process can effectively improve the biological and pharmacological activities of high-pressure-extracted C. lanceolata by increasing the extraction efficacy and inducing probiotic conversion. The results suggest that the combined treatment of HPE and a fermentation process could be used as alternative extraction method over CE.
Description Author Affiliation: He X ( Division of Biomaterials Engineering, Kangwon National University, Chuncheon, Gangwon 200-701, Republic of Korea.)
ISSN 13891723
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-08-01
Publisher Place Japan
e-ISSN 13474421
Journal Journal of Bioscience and Bioengineering
Volume Number 112
Issue Number 2


Source: WHO-Global Index Medicus