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Author Peters, Alan ♦ Sethares, Claire
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Philosophy & psychology ♦ Psychology ♦ Natural sciences & mathematics ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Incidence & prevention of disease ♦ Diseases
Subject Domain (in MeSH) Cardiovascular System ♦ Nervous System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Animal Diseases ♦ Diseases ♦ Mental Disorders ♦ Psychiatry and Psychology ♦ Physiological Phenomena ♦ Biological Sciences
Subject Keyword Discipline Neurology ♦ Aging ♦ Pathology ♦ Blood-brain Barrier ♦ Capillaries ♦ Cerebral Arteries ♦ Cerebral Cortex ♦ Blood Supply ♦ Cognition Disorders ♦ Physiology ♦ Animals ♦ Physiopathology ♦ Etiology ♦ Disease Models, Animal ♦ Macaca Mulatta ♦ Journal Article ♦ Research Support, N.i.h., Extramural
Abstract The effects of age on cerebral capillaries have been examined in area 46 of the prefrontal cortices of sixteen rhesus monkeys, ranging in age from 5 to 35 years. Fourteen of the monkeys had been behaviorally tested prior to their brains being prepared for electron microscopic examination. It was found that whereas the thickness of the outer basal lamina adjacent to the glial limiting membrane increased with age and showed increasing numbers of splits, the inner basal lamina between endothelial cells and pericytes did not become thicker with age, and did not show splitting. There were also no age-related changes in the extent of the coverage of endothelial cells by pericytes and no change in the frequency of mitochondria in endothelial cells. The factors that did change with age, namely, the thickness of the outer basal lamina and the increased numbers of splits in this lamina showed no correlations with the cognitive status of the monkeys, suggesting that thickening of the outer basal lamina does not contribute to cognitive decline.
Description Country affiliation: United States
Author Affiliation: Peters A ( Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. valan@bu.edu)
ISSN 00219967
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-04-15
Publisher Place United States
e-ISSN 10969861
Journal Journal of Comparative Neurology
Volume Number 520
Issue Number 6


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Source: WHO-Global Index Medicus