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Author McFarlane, R. ♦ Hurst, S. ♦ Sabath, D. ♦ George, E. ♦ Argenyi, Z.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Biochemistry ♦ Natural history of organisms ♦ Microorganisms, fungi & algae ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Surgery & related medical specialties ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Cells ♦ Anatomy ♦ Eukaryota ♦ Viruses ♦ Organisms ♦ Neoplasms ♦ Hemic and Lymphatic Diseases ♦ Pathological Conditions, Signs and Symptoms ♦ Diseases ♦ Amino Acids, Peptides, and Proteins ♦ Nucleic Acids, Nucleotides, and Nucleosides ♦ Chemicals and Drugs ♦ Diagnosis ♦ Surgical Procedures, Operative ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Persons ♦ Persons
Subject Keyword Discipline Pathology ♦ Discipline Dermatology ♦ Lung Transplantation ♦ Adverse Effects ♦ Lymphoproliferative Disorders ♦ Pathology ♦ Plasmacytoma ♦ Skin Neoplasms ♦ Fatal Outcome ♦ Herpesvirus 4, Human ♦ Genetics ♦ Isolation & Purification ♦ Humans ♦ In Situ Hybridization ♦ Etiology ♦ Metabolism ♦ Therapy ♦ Male ♦ Middle Aged ♦ Plasma Cells ♦ Postoperative Complications ♦ Rna, Viral ♦ Analysis ♦ Syndecan-1 ♦ Case Reports ♦ Journal Article
Abstract Post-transplant lymphoproliferative disorder (PTLD) is a lymphoid proliferation that develops as a complication of solid organ or bone marrow transplants. Most cases usually present in the gastrointestinal tract, liver, kidney or lymph nodes. Plasmacytoma-like PTLD is an uncommon variant, and presentation in the skin is exceedingly rare. We present a case of plasmacytoma-like PTLD presenting as a leg mass in a 58-year-old male. Biopsy from the lesion exhibited atypical plasmacytoid and plasmablastic cells that showed lambda light chain restriction and stained positive for CD138 and Epstain-Bar virus early RNA by in situ hybridization. These findings were diagnostic of plasmacytoma-like PTLD. Only a few similar cases have been reported in the literature. The majority of these cases occurred in heart and kidney transplant patients. To our knowledge, this is the first reported case to occur in a lung transplant patient.
Description Country affiliation: United States
Author Affiliation: McFarlane R ( Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195-6100, USA.)
ISSN 03036987
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Case study ♦ Article
Publisher Date 2008-06-01
Publisher Place United States
e-ISSN 16000560
Journal Journal of Cutaneous Pathology
Volume Number 35
Issue Number 6

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Source: WHO-Global Index Medicus