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Author Hirano-Ali, Stefanie A. ♦ Bryant, Elizabeth A. ♦ Warren, Simon J.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Keyword Discipline Pathology ♦ Discipline Dermatology
Abstract An epithelial sheath neuroma (ESN) is a rare benign process of unknown pathogenesis, which is characterized histologically by multiple enlarged peripheral nerve fibers ensheathed by mature squamous epithelium. The histologic features can elicit concern for carcinomatous perineural invasion. The process is limited to the superficial dermis and is surrounded by a loose myxoid stroma, lymphocytic infiltrate and sometimes prominent infundibular cysts. The etiology of this peculiar entity has been debated and theories include a benign neoplasm, a hamartoma or an unusual reactive hyperplasia. There are only seven prior cases reported of ESN in the literature. Our case presented here is the first report to show connection of the ESN to the overlying epidermis and reactive epidermal hyperplasia. This suggests that ESN is indeed an unusual form of benign reactive hyperplasia. In addition, the clinical setting in this case was of pruritus and scratching in a background of papular urticaria, supporting the previous notion that ESN is probably a response to an external stimulus such as rubbing.
Description Country affiliation: United States
Author Affiliation: Hirano-Ali SA ( Dermatopathology Section, Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.); Bryant EA ( Dermatopathology Section, Department of Pathology and Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA.); Warren SJ ( Department of Dermatopathology, Clarian Pathology Lab, Indiana University, Indianapolis, IN, USA.)
ISSN 03036987
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Case study ♦ Article
Publisher Date 2016-06-01
Publisher Place United States
e-ISSN 16000560
Journal Journal of Cutaneous Pathology
Volume Number 43
Issue Number 6


Source: WHO-Global Index Medicus