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Author Cesinaro, Anna Maria ♦ Rusev, Borislav Chavdarov ♦ Kutzner, Heinz
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Body Regions ♦ Tissues ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Neoplasms ♦ Skin and Connective Tissue Diseases ♦ Diseases ♦ Macromolecular Substances ♦ Enzymes and Coenzymes ♦ Biological Factors ♦ Chemicals and Drugs ♦ Diagnosis ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Persons ♦ Persons
Subject Keyword Discipline Pathology ♦ Discipline Dermatology ♦ Hair Diseases ♦ Pathology ♦ Hair Follicle ♦ Hamartoma ♦ Antigens, Cd34 ♦ Metabolism ♦ Biological Markers ♦ Factor Xiiia ♦ Female ♦ Surgery ♦ Humans ♦ Immunohistochemistry ♦ Middle Aged ♦ Scalp ♦ Treatment Outcome ♦ Vimentin ♦ Case Reports ♦ Journal Article
Abstract Fibrofolliculoma is a benign skin lesion that, when multiple, can be part of the Birt-Hogg-Dube syndrome. We report on a case of solitary fibrofolliculoma arisen on the nose of a 63-year-old woman, with peculiar histological and immunohistochemical features. The lesion was characterized by the presence of bizarre multinucleated perifollicular stromal cells, positive for factor XIIIa, in a background of CD34-positive cells, and by a peripheral population of CD34-positive spindle cells organized in fascicles haphazardly infiltrating the deep dermis, and surrounded by scattered factor XIIIa-positive dendrocytes. We consider the bizarre perifollicular cellular component as an 'ancient' feature of fibrofolliculoma, hypothesis corroborated by the co-expression of CD34 and factor XIIIa, whereas the peripheral spindle cell fascicles represent a pseudosarcomatous proliferation of CD34-positive cells, normally surrounding adnexal structures, stimulated by factor XIIIa-positive dendrocytes.
Description Country affiliation: Italy
Author Affiliation: Cesinaro AM ( Department of Pathology, University of Modena e Reggio Emilia, Modena, Italy. cesinaro.annamaria@policlinico.mo.it)
ISSN 03036987
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Case study ♦ Article
Publisher Date 2010-09-01
Publisher Place United States
e-ISSN 16000560
Journal Journal of Cutaneous Pathology
Volume Number 37
Issue Number 9


Source: WHO-Global Index Medicus