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Author Batailler, Martine ♦ Droguerre, Marine ♦ Baroncini, Marc ♦ Fontaine, Christian ♦ Prevot, Vincent ♦ Migaud, Martine
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Genetics and evolution ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Nervous System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Amino Acids, Peptides, and Proteins ♦ Chemicals and Drugs ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Cell Physiological Phenomena ♦ Genetic Phenomena ♦ Biological Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons
Subject Keyword Discipline Neurology ♦ Gene Expression Regulation ♦ Hypothalamus ♦ Cytology ♦ Metabolism ♦ Microtubule-associated Proteins ♦ Biosynthesis ♦ Neurogenesis ♦ Physiology ♦ Neuropeptides ♦ Aged ♦ Animals ♦ Cohort Studies ♦ Female ♦ Humans ♦ Male ♦ Mice ♦ Mice, Inbred C57bl ♦ Sheep ♦ Species Specificity ♦ Young Adult ♦ Comparative Study ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract Neural stem and precursor cells persist postnatally throughout adulthood and are capable of responding to numerous endogenous and exogenous signals by modifying their proliferation and differentiation. Whereas adult neurogenesis has been extensively studied in the dentate gyrus of the hippocampal formation and in the subventricular zone adjacent to the wall of the lateral ventricles, we and others have recently reported constitutive adult neurogenesis in other brain structures, including the hypothalamus. In this study, we used immunohistochemistry to study the expression of the neuroblast marker doublecortin (DCX), and compared its expression pattern in adult ovine, mouse, and human hypothalamic tissues. Our results indicate that DCX-positive cells resembling immature and developing neurons occur in a wide range of hypothalamic nuclei in all three species, although with different distribution patterns. In addition, the morphology of DCX-positive cells varied depending on their location. DCX-positive cells near the third ventricle had the morphology of very immature neuroblasts, a round shape with no processes, whereas those located deeper in the parenchyma such as in the ventromedial nucleus were fusiform and showed a bipolar morphology. Extending this observation, we showed that among the cohort of immature neurons entering the ventromedial nucleus, some appeared to undergo maturation, as revealed by the partial colocalization of DCX with markers of more mature neurons, e.g., human neuronal protein C and D (HuC/D). This study provides further confirmation of the existence of an adult hypothalamic neurogenic niche and argues for the potential existence of a migratory path within the hypothalamus.
Description Country affiliation: France
Author Affiliation: Batailler M ( INRA, Unité Mixte de Recherche (UMR) 85 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France)
ISSN 00219967
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-06-01
Publisher Place United States
e-ISSN 10969861
Journal Journal of Comparative Neurology
Volume Number 522
Issue Number 8


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Source: WHO-Global Index Medicus