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Author Greaney, Marie R. ♦ Privorotskiy, Ann E. ♦ D'Elia, Kristen P. ♦ Schoppik, David
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Keyword Discipline Neurology
Abstract Both spatial and temporal cues determine the fate of immature neurons. A major challenge at the interface of developmental and systems neuroscience is to relate this spatiotemporal trajectory of maturation to circuit-level functional organization. This study examined the development of two extraocular motor nuclei (nIII and nIV), structures in which a motoneuron's identity, or choice of muscle partner, defines its behavioral role. We used retro-orbital dye fills, in combination with fluorescent markers for motoneuron location and birthdate, to probe spatial and temporal organization of the oculomotor (nIII) and trochlear (nIV) nuclei in the larval zebrafish. We describe a dorsoventral organization of the four nIII motoneuron pools, in which inferior and medial rectus motoneurons occupy dorsal nIII, while inferior oblique and superior rectus motoneurons occupy distinct divisions of ventral nIII. Dorsal nIII motoneurons are, moreover, born before motoneurons of ventral nIII and nIV. The order of neurogenesis can therefore account for the dorsoventral organization of nIII and may play a primary role in determining motoneuron identity. We propose that the temporal development of extraocular motoneurons plays a key role in assembling a functional oculomotor circuit. J. Comp. Neurol. 525:65-78, 2017. © 2016 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
Description Country affiliation: United States
Author Affiliation: Greaney MR ( Departments of Otolaryngology, Neuroscience & Physiology, and the Neuroscience Institute New York University Langone School of Medicine, New York, New York, USA.); Privorotskiy AE ( Departments of Otolaryngology, Neuroscience & Physiology, and the Neuroscience Institute New York University Langone School of Medicine, New York, New York, USA.); D'Elia KP ( Departments of Otolaryngology, Neuroscience & Physiology, and the Neuroscience Institute New York University Langone School of Medicine, New York, New York, USA.); Schoppik D ( Departments of Otolaryngology, Neuroscience & Physiology, and the Neuroscience Institute New York University Langone School of Medicine, New York, New York, USA.)
ISSN 00219967
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2017-01-01
Publisher Place United States
e-ISSN 10969861
Journal Journal of Comparative Neurology
Volume Number 525
Issue Number 1


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Source: WHO-Global Index Medicus