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Author Depuydt, Pieter O. ♦ Benoit, Dominique D. ♦ Roosens, Carl D. ♦ Offner, Fritz C. ♦ Noens, Lucien A. ♦ Decruyenaere, Johan M.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Elsevier
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Social sciences ♦ Social problems & services; associations ♦ Social welfare problems & services ♦ Natural sciences & mathematics ♦ Life sciences; biology ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Neoplasms ♦ Respiratory Tract Diseases ♦ Pathological Conditions, Signs and Symptoms ♦ Diseases ♦ Diagnosis ♦ Therapeutics ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Persons ♦ Persons ♦ Health Care Facilities, Manpower, and Services ♦ Health Care
Subject Keyword Discipline Critical Care ♦ Hematologic Neoplasms ♦ Complications ♦ Anoxia ♦ Therapy ♦ Positive-pressure Respiration ♦ Methods ♦ Respiratory Insufficiency ♦ Acute Disease ♦ Female ♦ Mortality ♦ Hospital Mortality ♦ Humans ♦ Etiology ♦ Intensive Care Units ♦ Male ♦ Middle Aged ♦ Multivariate Analysis ♦ Prognosis ♦ Regression Analysis ♦ Retrospective Studies ♦ Severity Of Illness Index ♦ Survival Analysis ♦ Treatment Outcome ♦ Evaluation Studies ♦ Journal Article
Abstract PURPOSE: The aim of this study was to assess the impact of the 3 types of initial respiratory support (noninvasive positive pressure ventilation vs invasive positive pressure ventilation vs supplemental oxygen only) in hematological patients with acute hypoxemic respiratory failure (ARF). MATERIALS AND METHODS: This study is a retrospective analysis of a cohort of hematological patients admitted to the intensive care unit (ICU) of a tertiary care hospital between January 1, 2002, and June 30, 2006. RESULTS: One hundred thirty-seven hematological patients were admitted at the ICU with ARF (defined as Pao(2)/Fio(2) <200): within the first 24 hours, 24 and 67 patients received noninvasive positive pressure ventilation and invasive positive pressure ventilation, respectively, and 46 received supplemental oxygen only. Intensive care unit mortality in the 3 patient categories was 71%, 63%, and 32%, respectively (P = .001), and in-hospital mortality was 75%, 80%, and 47%, respectively (P = .001). In multivariate regression analysis, increasing cancer-specific severity-of-illness score upon admission and more organ failure after 24 hours of ICU admission, but not the type of initial respiratory support, were significantly associated with ICU or in-hospital mortality. CONCLUSIONS: Intensive care unit and in-hospital mortality in our population of hematological patients with hypoxemic ARF was determined by severity of illness and not by the type of initial respiratory support.
Description Country affiliation: Belgium
Author Affiliation: Depuydt PO ( Department of Intensive Care Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium. pieter.depuydt@ugent.be)
ISSN 08839441
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2010-03-01
Publisher Place United States
e-ISSN 15578615
Journal Journal of Critical Care
Volume Number 25
Issue Number 1


Source: WHO-Global Index Medicus